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3.
Rev. Inst. Med. Trop. Säo Paulo ; 36(3): 217-23, maio-jun. 1994. ilus
Article in English | LILACS | ID: lil-140166

ABSTRACT

Estudou-se sequencialmente, a microscopia eletronica de transmissao, a interacao entre Paracoccidioides brasiliensis (Pb) e celulas inflamatorias em hamsters inoculados por via intratesticular. Seis horas apos inoculacoes havia predominancia de neutrofilos, estando presentes algumas celulas mononucleares e eosinofilos. Os neutrofilos foram progressivamente substituidos por celulas mononucleares. Fungos viaveis apresentavam-se fagocitados ou circunscritos por celulas inflamatorias, geralmente com ampla interface hospedeiro-parasita. Fungos mortos ou degenerados eram acompanhados de interfase estreita. A camada externa da parede do Pb era as vezes quebrada quando em contato com neutrofilos, em varios pontos, sendo os fragmentos dessa parede descamados e fagocitados....


Subject(s)
Animals , Male , Paracoccidioidomycosis/pathology , Host-Parasite Interactions , Rodentia/parasitology , Paracoccidioidomycosis/microbiology
4.
Article in English | AIM | ID: biblio-1268785

ABSTRACT

One hundred and four fecal specimen of children under five years reporting to Malindi Hospital were analysed for diarrhoegenic agents. These included bacterial; viral and parasitic agents which may cause diarrhoea. Conventional methods were employed in this study. The children were also examined for malaria parasites. consistency of the stool samples was loose 49; watery 26; formed 16; mucoid 9 and 3 of the specimen had traces of blood. 29 of the children were positive for malaria. Detection of diarrhoegenic agents was as follows;- 1. Bacteria 34; the highest of these being pathogenic Escherichia coli 39; Salmonella 28; Shigella 28 and Vibrio parahaemolyticus 3; 2. Rotaviruses 28; 3. Parasites 10 which included Ascaris lumbricoides 44; Trichuris trichura 33; Giardia lamblia 22 and Entamoeba coli 11. Mixed infections were observed in 7 of the subjects. Aetiological agents of diarrhoea could not be detected in 30 of the specimen


Subject(s)
Diarrhea , Diarrhea/etiology
5.
Article in English | AIM | ID: biblio-1268786

ABSTRACT

A study to determine the in vitro activity of antibiotics to bacterial pathogens isolated from diarrhoea stools of 125 patients reporting to the Paediatric Filter Clinic at Malindi District Hospital with acute diarrhoea was done. The ages of the patients ranged from one to five years. Samples of diarrhoea stools were collected before drug administration. 33 strains of Enterobacteriacea comprising 12 strains of pathogenic Escherichia coli; 13 strains of Salmonella SPP and 8 strains of Shigella SPP were isolated and minimum inhibitory concentration of five antibiotics determined. 5 pure antibiotic powders; namely; ampicillin; tetracycline; kanamycin; trimethoprim-sulfamethoxazole and nalidixic acid were tested using the agar dilution method (Muellerinton agar). The minimum inhibitory concentration (MIC) of the 5 antibiotics used ranged between 8#gml-1 and 128#gml-1 excep for t trimethoprin-sulfamethoxazole which had a MIC range of 0.25#gml-1 to 16#gml-1. Hyper resistance of the isolates was observed for ampicillin; tetracycline; kanamycin and nalidixic acid. The results of this work suggest that there is circulation of resistant strains of bacteria causing diarrhoea within the community around Malindi


Subject(s)
Anti-Bacterial Agents , Diarrhea , Diarrhea/drug therapy , Drug Evaluation , Infant
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